What is the Haematology Specialised Register?
The Specialised Register of Haematology was established in Febuary 2005 and is a continuously growing database of reports of randomised controlled trials (RCTs) and controlled clinical trials (CCTs) relevant to the scope of Cochrane Haematology.
The focus is specifically on the following haematological disorders and interventions:
- Acute lymphoblastic leukaemia (ALL)
- Acute myeloid leukaemia (AML)
- Chronic myeloid leukaemia (CML)
- Chronic lymphocytic leukaemia (CLL)
- Hodgkin lymphoma (HL)
- Multiple myeloma (MM)
- Non-Hodgkin's lymphoma (NHL)
- Myelodysplastic syndromes (MDS)
- Aplastic anaemia (AA)
- Other haematological diseases
- Stem cell transplantation (SCT)
- Haematopoietic growth factors in oncology
It contains about 12.000 reports of RCTs and CCTs (01.02.2020). Reports are submitted for inclusion in the Cochrane Central Register of Controlled Trials (CENTRAL) on a monthly basis.
CENTRAL is comprised of records retrieved from PubMed/Medline, Embase, ClinicalTrials.gov, WHO's ICTRP, KoreaMed, all Cochrane Review Groups' Specialized Registers, and records identified by handsearching various biomedical sources, as described below.https://www.cochranelibrary.com/central/about-central
Identifying RCTs and CCTs for the register:
The information specialist is responsible for identifying trials and maintaining the register.
A detailed search strategy for Medline (via Ovid) has been developed to assist identification relevant trials. Details of this search strategy can be found here. LINK
Retrospective searches were taken in Medline (via Ovid) and Central (February 2005).
Since 2014 we additionally include reports of trials which concern stem cell transplantation and haematopoietic growth factors in oncology.
The specialised register also contains records obtained through handsearching activities of conference proceedings related to our scope. Nevertheless, handsearching activities were ended, because nowadays the far majority of conference proceedings are being indexed in EMBASE and so thus be found in CENTRAL. Details of previous handsearching activities are available here. LINK
The searches in Medline and screening of possible RCTs and CCTs are conducted by the Cochrane Haematologies Editorial Base. Since August 2018, all records eligible for screening are run through a machine learning tool available in Cochranes Register of Studies, called the RCT classifier. The RCT classifier is set at a 99% recall (or sensitivity) and reduces the number of records which are needed to be screened about 60 %.
All remaining records are screened by the information specialist for inclusion in the Haematology Specialised Register and are added to CENTRAL. The monthly search in Medline identifies around 20-30 new references.
The Specialised Register with all RCTs and CCTs can be accessed via CENTRAL in the Cochrane Library https://www.cochranelibrary.com/central/about-central and in contact with the information specialist.